In an ovalbumin asthma mouse model, the membrane impermeable nAChR agonist 1,1-dimethyl-4-phenylpiperazinium (DMPP) was able to attenuate the airway hyperresponsiveness, a hallmark of asthma, and airway inflammation by reducing lymphocyte and eosinophil numbers in the bronchoalveolar lavage fluid and tissue infiltration by mononuclear cells and eosinophils [51]. Here, CHRNA4 is linked to asthma.