Although it is commonly hypothesized that liver triglyceride contributes to hypertriglyceridemia and systemic insulin resistance, in this cohort, there was no significant correlation between hepatic triglyceride levels and either serum triglyceride or serum insulin, indicating that liver fat per se was not a major determinant of either fructose-induced hypertriglyceridemia or hyperinsulinemia. This evidence concerns the gene INS and hyperinsulinism.