MAPK3 and cancer: Figure 5 shows the median variation of each analyte considered. The same subpopulation, together with IRS1 downregulation (z = −4.20, p < 1 × 10−5) in esophageal tissue affected by Barrett’s lesion, importantly showed a decreased amount of total Akt (z = −2.62, p = 0.009), total p70S6K (z = −3.47, p = 5 × 10−4), and total ERK1/2 protein (z = −4.04, p = 1 × 10−4). Twenty-three patients in total (n = 20 IA and n = 3 CA patients) belonged to this lower-IRS1 and improved metabolic parameters group (Figure 5).