GDF-15 has been found to control appetite, reduce body weight, increase thermogenesis, lipolysis and oxidative metabolism, improve insulin sensitivity and glucose tolerance [12] The diseases that involve organ damage (myocardial infarction, renal failure) or those which involve chronic inflammation (diabetes mellitus) elevate the GDF-15 concentrations [10,11]. This evidence concerns the gene GDF15 and Renal insufficiency.