Gene expression results were suggestive of enhanced hepatic fatty acid catabolism (upregulated Ppara and Ppargc1a), enhanced autophagy and, hence, possible lipophagy (upregulated Atg7, Becn1 and Foxo3a) and decreased de novo lipogenesis (downregulated Gck) in the BC+MET group compared with the other HFD-fed groups. The gene discussed is GCK; the disease is breast cancer.