Further, two-way ANOVA analysis of the HFD-fed groups indicated a significant or nearly significant effect of BC lowering fasting blood glucose (p = 0.004), insulin (p = 0.047) and HOMA-IR (p = 0.053), and no significant effect of MET on these parameters (p = 0.106, p = 0.610 and p = 0.351, respectively). This evidence concerns the gene INS and breast cancer.