Trends to HFD-induced decreases in the expression of Ppargc1a (encoding PGC1ɑ, a key transcriptional coactivator for cellular oxidative metabolism), Mfn2 (encoding MFN2, related to the transfer of fatty acids to the mitochondria for oxidation [35,37]) and lipolytic genes Lipe and Pnpla2 (encoding hormone-sensitive lipase and adipose triglyceride lipase, respectively) were present in the HF control group, more marked in the BC group, yet lacking in the BC+MET group. The gene discussed is PPARGC1A; the disease is breast cancer.