Adopting sedentary behaviors over a long period of time could limit overall energy expenditure by muscle contraction and impair lipoprotein lipase activity, which leads to the inhibition of triglyceride uptake by skeletal muscles and impedes fat metabolism in peripheral tissues; thus, the role of sedentary behavior might indirectly affect fat metabolism in the liver and further be related to the etiology of NAFLD [29,49]. Here, LPL is linked to metabolic dysfunction-associated steatotic liver disease.