Histologic evidence of colonic inflammation in the ex-GF IL10−/− mice colonized with pooled IBD fecal microbiota was most prominent in the cecum and rectum, as noted in SPF 129SvEv IL10−/− mice [21] and ex- GF IL10−/− mice humanized with feces from a healthy human donor [4]. The gene discussed is IL10; the disease is inflammatory bowel disease.