Other factors, so-called nutrient sensors (e.g., insulin, insulinlike growth factor (IGF-1), mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK)) operate in the Warburg Effect, with their pathways playing important and complimentary roles in cellular proliferation and cancer expression [33,34,35,36,37]. Here, INS is linked to cancer.