This effect was also observed in other clinical and preclinical NASH studies, presenting a significant regression of Tnfα mRNA expression after L-carnitine supplementation [56], after glycine treatment [64] or in NR-treated mouse livers [65,77,78], supporting the hypothesis that NR treatment improves hepatic inflammation by modulating pyrin domain containing 3 (NLRP3) inflammasome. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.