These patients did not present differences also in metabolic parameters, the parameters of glycaemic control (HbA1c, mean daily BG, mean fasting BG, mean pre-lunch BG, mean pre-dinner BG, mean postprandial BG, mean coefficient of variation), the mean insulin dose or the main parameters used for the variability evaluation (LBGI, HBGI, GRADE, J-index, MODD, ADRR, hypoglycaemia index, MAGE, hyperglycaemia index, index of Glycaemic Control, nocturnal and morning hypoglycaemia episodes per month, etc.)(Table 1 and Table 2). This evidence concerns the gene INS and Hypoglycemia.