These clinical trials also evaluated cardiometabolic outcomes and found a greater reduction in insulin levels, HOMA-IR score, triglycerides, VLDL-cholesterol, total antioxidant capacity, total glutathione, and nitric oxide in overweight and women with obesity with polycystic ovary syndrome after a calorie-restricted DASH diet [91,92,93,94] (Table 3). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.