Sandu et al. showed that, after 6 months on high-fat (HF) and H-AGEs (H-AGEs-HF) diet, 75% of normal C57/BL6 mice were diabetic and exhibited higher body weight, fasting glucose, insulin, serum AGEs, impaired glucose and insulin responses during glucose tolerance tests, euglycemic and hyperglycemic clamps, altered pancreatic islet structure and function, higher plasma 8-isoprostanes, and lower adiponectin levels, compared with those on L-AGEs-HF diet. Here, INS is linked to hydrops fetalis.