From the studies that described NASH conditions in patients, in the first trial, highly purified EPA improves some NASH characteristics, including decreased serum ALT and AST levels as well as hepatic steatosis grade, with biopsy histology assessment showing improvement in several key features of NASH, such as hepatic steatosis, fibrosis, lobular inflammation and hepatocellular ballooning [162]. The gene discussed is GPT; the disease is fatty liver disease.