In detail, in the presence of the “carbohydrate intake-decreasing allele” of the FGF-21 genetic variant, it seems that a low-calorie, high-carbohydrate and low-fat diet improves abdominal obesity and that, conversely, there is a smaller reduction in abdominal obesity in response to a low-carbohydrate and high-fat diet [83]. Here, FGF21 is linked to Abdominal obesity.