INS and obesity due to melanocortin 4 receptor deficiency: Various complex interplaying mechanisms can help explain the hypertension-promoting action of a progressively higher body fat content and obesity, including overactivation of the sympathetic nervous system (SNS) [4,47,48,49,50,51], inappropriate renin–angiotensin–aldosterone system (RAAS) stimulation [5,52,53,54,55,56,57,58,59], modifications induced by adipocyte-derived cytokines (i.e., leptin) [60,61,62,63,64], structural and functional renal changes [65,66,67], and reduced insulin sensitivity [68,69,70,71,72].