Albeit that FoxP3 expressing T cells do not differ in numbers during uncomplicated or severe malaria cases, Tr1 co-producing IL10 and IFNγ were reported to be higher during uncomplicated malaria compared to severe malarial cases [87] where FoxP3+ T cells with a potent suppressor capacity, recognized by TNFR2 expression, were more common [88,89]. The gene discussed is IFNG; the disease is malaria.