We also confirmed here the involvement of SOCE-mediated Ca2+ signaling in EBV-driven NPC development by showing that STIM1, an essential component of the SOCE channel, is upregulated by EBV infection in NPC cells and helps mediate the ability of EGF to induce Ca2+ influx via SOCE, which in turn drives tumor angiogenesis. Here, STIM1 is linked to nasopharyngeal carcinoma.