CMPK2 and infection: For the interferon regulated genes, Ct infection induced a significant increase in the MX1 and MX2 mRNA fold change (between ~2 and 3.5) at 12, 24 and 36 hpi, while CMPk2 mRNA fold change increased between 36 and 48 hpi to ~2.6 and 2, respectively (Figure 3).