MMP-3 (stromelysin-1) is a notable proteolytic enzyme among the other MMP types due to its central role in activating the latent MMP types such as MMP-7, MMP-8, MMP-9, and MMP-13, and it has been claimed that MMP-3 has a pivotal function in the initiation of collagen disintegration in periodontitis [5]. The gene discussed is MMP8; the disease is periodontitis.