In the mouse keratitis model [47], as in silencing HMGB1 (siRNA use), recombinant (r) TM, composed of TM domains 1-4, (Leu 17-Ser 517), treatment led to better clinical disease scores in treated mice after after infection and slightly (1 log) lessened the plate count in cornea. This evidence concerns the gene HMGB1 and keratitis.