CD40LG and infection: In line with infection responses, human seronegative volunteers receiving WCV have exhibited phase I-specific IgM responses with a minor phase II-specific IgM and IgG components, while seropositive volunteers receiving WCV displayed Phase I-specific IgA, IgG, and IgM responses along with phase II-specific IgG and complement fixing responses, mirroring the humoral profile of those experiencing a positive skin test [58,59].