In addition, assessing the frequencies of gene-gene combination (NAT2 with GSTM1, XPD, and CYP1A1) between cases with laryngeal cancer and the controls, the frequency of combinations was superior to cases than in controls where the numbers of combinations had an increased risk of laryngeal cancer and the numbers of other combinations had a protective role [40]. This evidence concerns the gene CYP1A1 and laryngeal carcinoma.