Several risk factors contribute to the development of tendinopathy including genetic susceptibility (i.e., polymorphisms in collagen type V alpha 1 chain- COL5A1, Tenascin C-TNC, Matrix Metallopeptidase 3-MMP3 and Estrogen Related Receptor Alpha- ESRRA), chronic diseases (i.e., diabetes), or specific pharmacological therapies (i.e., quinolone antibiotics) [1]. The gene discussed is ESRRA; the disease is diabetes mellitus.