P2RX7 and cancer: In addition, several studies revealed the inhibition of proliferation, metastasis and angiogenic processes in diverse cancer cells by the use of ivermectin via targeting multiple signaling pathways including EGFR/ERK, PAK1 kinase, Akt/mTOR, P2X7/P2X7 WNT-TCF SIN3 domain NS3 DDX23 helicase and chloride channels [26,33].