Up to now, the allele frequency of the three most common MEFV mutations E148Q, V726A, and M694V in IgA nephropathy cases is comparable to the ethnically adjusted general population distribution, and does not demonstrate a disease specificity nor a correlation with the clinical course of this glomerulonephritis in FMF patients [32,33,34,35]. This evidence concerns the gene MEFV and familial Mediterranean fever.