TERT and myeloproliferative neoplasm: Genes involved in cells senescence, such as TERT in JAK-STAT signalling; SH2B3 in myeloid differentiation; GFI1B in DNA damage and repair; ATM and CHEK2 in epigenetic regulators; and TET2 were identified as targets of several additional predisposition loci in MPN onset [43].