If we consider that the increased expression of VDR in cultured C2C12 cells (myoblasts) treated with 1α,25(OH)2D3 and 25(OH)D3 alters their proliferation and differentiation [44], it might be hypothesized that vitamin D deficiency can cause an impairment in the healing process in patients who have suffered a direct trauma or have sustained a damaging functional stress (e.g., eccentric exercise). The gene discussed is VDR; the disease is vitamin D deficiency.