Cofetuzumab pelidotin, also known as PF-06647020 or ABBV-647, is an ADC containing Auristatin-0101 as payload linked, through a cathepsin cleavable linker, to a monoclonal antibody targeted to protein tyrosine kinase 7 (PTK7) [36], that is upregulated in several cancer types, including colon, breast, and esophageal tumors among others. This evidence concerns the gene PTK7 and cancer.