Moreover, IVT injections have been reported to exacerbate the systemic side effects of anti-vascular endothelial growth factors (Anti VEGF) when used for their delivery to the posterior eye, causing life-threatening cardiovascular as well as cerebrovascular side effects including myocardial infarctions, transient ischemic attacks, deep vein thrombosis, pulmonary embolisms and thrombophlebitis [10]. The gene discussed is VEGFA; the disease is deep vein thrombosis.