Therefore, we investigated whether mild MHT could modulate the expression of NK cell ligands such as MICA, ULBP-1, ULBP-2 (NKG2D ligands); Nectin-2, PVR (DNAM-1 ligands); B7H6 (NKp30 ligand); HLA class I (HLA-I or HLA-ABC) and HLA-E on GBM cells. This evidence concerns the gene CD226 and glioblastoma.