EGF and breast carcinoma: Another study found that extracellular vesicle delivery of let-7a miRNA had potent antitumor effects on breast cancer cells breast cancer cells, and that extracellular vesicles expressing GE11 or AS1411, to target epidermal growth factor or nucleolin, respectively, on breast cancer cells, could enhance the effects of let-7a miRNA by enhancing delivery of their payload to the tumor cells [117,147].