CXCL8 and neoplasm: With consideration of the category named “immune responses”, the thermo-chemotherapeutic tumor therapy and magnetic hyperthermia alone both induced a persistent up-regulation of leukocyte extravasation signaling, IL-8 Signaling, and Fcα receptor-mediated phagocytosis in macrophages and monocytes, while tumor treatment with 5FU as monotherapy led to down-regulation of pathways involved in cellular immune response (long-term post observation time, Figure 6).