SMAD3 and neoplasm: Hereto, the predicted regulator for the combined thermo-chemotherapeutic tumor therapy were found to belong mostly to the group of cell death/survival associated transcription factors, such as TGF beta, PDGF, ERK, SMAD3, PI3K, STAT3, etc. Further upstream regulators were mainly linked to the inflammatory response and cytokine signaling, including IL-6, CCR2, CEBPB, CSF2, and IgE (Figure 7).