F2 and neoplasm: Global proteomic analyses revealed 10 pertinent canonical pathways for the thermo-chemotherapeutic tumor treatment, such as GP6 signaling pathway, acute phase response signaling, intrinsic prothrombin activation, integrin signaling, coagulation system, etc. The thermo-chemotherapeutic tumor treatment presented upregulated canonical pathways associated with the functional categories “cellular stress and injury”, “intracellular and second messenger signaling” and “nuclear receptor signaling” “growth proliferation and development” and “immune responses”.