Based on recent clinical research, mostly performed with [68Ga]PentixaFor, CXCR4 is now an established target for PET imaging of hematologic tumors including non-Hodgkin lymphoma, multiple myeloma, chronic lymphocytic leukemia, acute myeloid leukemia and Waldenström macroglobulinemia [6]. Here, CXCR4 is linked to plasma cell myeloma.