Synthetic progestins, such as MPA, can act on Bcl-2 expression not only in breast cancer cells or endometrial cancer cells, but also in colonic carcinoma and pancreatic carcinoma cells, causing apoptosis by mechanisms that include Bcl-2downregulation and phosphorylation, which decrease Bcl-2 function [103]. This evidence concerns the gene BCL2 and breast carcinoma.