EZH2 and cancer: Experimental studies have shown that curcumin can inhibit EZH2 (enhancer of zest homolog-2), which is a histone methyltransferase that catalyzes the trimethylation of histone H3 in lys 27 (H3K27me3), is found in an increased amount in human cancer, has an oncogenic, metastatic role, and influences drug resistance.