The inhibition of NRF2 or p62/SQSTM1 with distinctive siRNA proved the existence of the communication channel between the two molecules, and that the easily disassemble of any molecule surged the killing of cancer cells by Zn (II)–curc, a fact that could be implemented in the future to improve the receptivity to tumors treatment by this method [70]. This evidence concerns the gene SQSTM1 and cancer.