CASP3 and Ewing sarcoma: Caspase 3/7 activation after ML111 treatment is reproducible in CHP100, A673, and TC-32 Ewing’s sarcoma cell lines (Figure S1); dasatinib, another multikinase inhibitor with a broad-spectrum kinase-inhibition profile, was used in the latter studies to ascertain selectivity of ML111 in inducing apoptosis.