In order to identify new agents that inhibit the viability of Ewing’s sarcoma cells, we conducted a phenotypic, high-throughput screen (HTS) using SK-ES-1 cells, a well characterized Ewing’s sarcoma cell line harboring a type II EWS-FLI1 oncofusion protein [24,25] and a chemical library composed of small molecules from the ChemBridge DIVERSet-CL and CORE Libraries (https://www.chembridge.com/screening_libraries (accessed July 2016)). The gene discussed is FLI1; the disease is Ewing sarcoma.