PHH and cultured human hepatoma cells, including HepG2, Huh7, and HepaRG cells, have shown a significant downregulation of P-gp, BCRP, and MRP2 mRNA levels after an exposure for 24 h to IL-6, IL-1β and IFN-γ [93,94]. The gene discussed is ABCG2; the disease is hepatocellular carcinoma.