These liposomes were proposed for combination therapy; the in vitro test showed that they were able to deliver DOX efficiently and improve its cytotoxicity in CXCR4-expressing cell lines, while they were able to deliver the drug to melanoma lung metastases in vivo efficiently and reduce metastasis formation thanks to their antagonistic CXCR4 activity [98]. The gene discussed is CXCR4; the disease is melanoma.