AZGP1 and obesity due to melanocortin 4 receptor deficiency: On the other hand, future studies should investigate whether the increase in Zn levels after melatonin supplementation exclusively in the perirenal WAT in this diabesity animal model could be related to a higher expression of ZFP407 or even zinc-2-glycoprotein (ZAG) in the adipocytes of this WAT, whose expression is clearly reduced in adipose tissues, mainly in the subcutaneous tissue, in the pathologies of obesity [61].