Moreover, the oral administration of L. kefiranofaciens strain M could alleviate the progression of type-1 diabetes (T1D) symptoms in streptozotocin-induced T1D murine model by stimulating the production of glucagon-like peptide-1 (GLP-1), regulating the immune-modulatory reaction and modifying the gut microbiota [133]. This evidence concerns the gene GCG and type 1 diabetes mellitus.