Similar to Sal4, a biologically active secretory-like IgA and IgM (SCIgA/M) antibody protected mice from intragastric infection with a virulent strain of STm as revealed by reduced colonization of both mucosal and systemic compartments, and preserved integrity of the Peyer’s patches through immune exclusion of bacterial aggregates [250,251]. The gene discussed is CD79A; the disease is infection.