IL10 and infection: Given the reported higher production of IL10 associated with the IL10 GCC haplotype [26], these results suggested that IL10 variants influence the clearance of infection with high-risk HPV types because higher levels of IL10 may impair the production of inflammatory cytokines such as IL-2, TNF-α, IL-4, IL-6 and IL-12 that are involved in the TH1-TH2 immunoregulation and immunity against HPVs.