Similarly, the variant rs13211972 in the 6p21.33 region correlated with a significant decrease in mRNA expression levels of MICA and an increased risk of SCCHN [99] thus substantiating the relevance of MICA expression in carcinogenesis, including other virus-associated cancers, such as in EBV+ nasopharyngeal carcinoma [101] and hepatitis B virus (HBV)-induced hepatocellular carcinoma [102]. Here, MICA is linked to head and neck squamous cell carcinoma.