A GWAS in women of European-ancestry, including in 1075 cervical cancer cases and 4014 controls and replicated it in 1140 case subjects and 1058 control subjects identified three independent loci in the MHC region at 6p21.3 in association with cervical cancer, including the variant rs2516448, adjacent to the MHC class I polypeptide-related sequence A gene (MICA); the rs9272143, between HLA-DRB1 and HLA-DQA1, and the rs3117027, at HLA-DPB2. The gene discussed is HLA-C; the disease is cervical cancer.