TP53 and squamous cell intraepithelial neoplasia: However, in an updated meta-analysis of 49 publications (7269 patients with invasive cervical cancer or premalignant cervical lesions, and 5326 healthy controls) the Arg variant of p53 Arg72Pro was associated with progression of squamous intraepithelial lesions (SIL) to cervical cancer only in the presence of HPV positivity [117].