LMLN and infection: Given this shift in the location of the GP63 within the parasite, it is unclear whether the later stage macrophage infections, which harbor the amastigotes, continue to release GP63 into the exosomes [4,5,34,40,81], and it is not known whether the parasite molecules synthesized in the amastigotes found in the macrophages in long-term infections are released into the exosomes [35,40,54,68].