Significant downregulation of the hepatic gene expression of the lipogenic markers in the HFD group by the A. muciniphila strains was also observed as follows: SREBP-1c and ACC by P.A and L.A; FAS by P.B and L.B. Overall, these findings support the hepatoprotective activities of both A. muciniphila strains against HFD-induced steatosis, which is in agreement with an earlier report [26]. The gene discussed is FAS; the disease is steatosis.