The outcomes showed how chronic periodontitis, considered a complex pathology, represents a significant imbalance between pro-inflammatory and anti-inflammatory gene expression such those regulating IL-10 gene and IL-6, tumor necrosis factor alpha (TNFα), IL-1α-β-RN (IL-1α-β-RN), collagen type-l alpha (COLIA1), and vitamin D receptor (VDRs) genes [68,69,70,71,72,73,74]. Here, TNF is linked to periodontitis.