CD4 and lymphopenia: Though it remains unclear how these phenomena should be interpreted in the context of COVID-19 lymphocytopenia, it can be assumed that cytotoxins, suppressor T cells, and macrophages (M1) GM-CSF (CD80–86) may all be factors in secondary uncontrolled IL-6 responses while decreasing T cells (Treg), gamma/delta T cells (T-ɣδ), and CD4 immune modulating responses [9,15,16,17].