In addition, the search for single nucleotide polymorphisms (SNPs) may unveil the involvement of specific immune regulatory genes, such as those like IL-10, IL-6, and VDR or those that instruct human cells to build the receptor ACE2 that would explain the upsurge of the uncontrolled “cytokine storm” that drives severe COVID-19 multiple organ failures and death. This evidence concerns the gene IL10 and COVID-19.