In the study, relevant traits as lymphopenia (PP = 64%), low level of B-lymphocytes (PP = 60%), low level of T-reg CD4+CD25+high (PP = 37.8%) and high level of T killer cells (PP = 73.3%), high level of CD8+CD57+ suppressor (PP = 64.44%), high level of CD8+CD38+DR+ (80%), and monocytes (PP = 28.9%) were seen in COVID-19 patients. The gene discussed is CD38; the disease is COVID-19.