The genomes of BE cells are known to become highly altered during their evolution [46], with many somatic mutations (e.g., TP53 inactivation) [47,48], chromosomal alterations and rearrangements [44,45], and epigenetic modifications [49,50] (e.g., age-related hypermethylation) accruing during the progression from BE to EAC (Figure 1). Here, TP53 is linked to Barrett esophagus.