In particular, in the multivariate analyses, among factors regarding patient characteristics, tumor burden, and laboratory data, only AST increase (>46%) and ALT increase (>52%) resulted significantly correlated with the objective (p = 0.03 and p = 0.04, respectively) and complete (p = 0.02 and p = 0.02, respectively) response, taking into account only the response of the target lesions. The gene discussed is GPT; the disease is neoplasm.