After exclusion of edoxaban 30 mg, we observed the significant stroke reduction for both types of NOAC: dabigatran vs. warfarin-RR 0.81, 95% CI 0.67–0.98; FXa inhibitors vs. warfarin-RR 0.84, 95% CI 0.76–0.92); and NOAC together-RR 0.83 95% CI 0.76–0.90 (Supplementary Figure S8A). Here, F10 is linked to Stroke.