A recent Phase I study found that the combination of gilteritinib and venetoclax in R/R FLT3-mutant AML achieved a modified composite CR (CR + CRp + CRi + MLFS) of 76.4%, including a significant proportion (62.5%) of patients with prior FLT3 TKI exposure, in contrast to 12% in the ADMIRAL study [15]. This evidence concerns the gene FLT3 and acute myeloid leukemia.