In addition, a recently proposed polygenic risk score for prediction of CRC yielded an AUC-ROC of 0.65 [24], while another five-marker blood test (carcinoembryonic antigen + anti-p53 + osteopontin + seprase + ferritin) only had an AUC-ROC of 0.56 [25]. This evidence concerns the gene SPP1 and colorectal carcinoma.